Triethylamine → 5-Amino-2-(ethoxymethyl)-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Triethylamine (5.28 ml, 37.9 mmol) was added with stirring to a suspension of 2-aminomalononitrile 4-methylbenzenesulfonate (8 g, 31.6 mmol) in THF (120 ml) to give a light brown solution. 1,1,1,2-Tetraethoxyethane (7.82 g, 37.9 mmol) was added and the reaction mixture was stirred under argon at reflux temperature. After 4 h an additional amount of 2.3 g 1,1,1,2-tetraethoxyethane was added and the mixture heated for another 2 h. The mixture was allowed to cool to room temperature, triethylamine (5.28 ml, 37.9 mmol) and 1-amino-2-methylpropan-2-ol (3.63 ml, 37.9 mmol) were added and the reaction was stirred overnight. The mixture was concentrated in vacuo, and the residue was partitioned between ethyl acetate (200 mL, 2×150 mL) and sodium bicarbonate solution (2 M, 100 mL). The organic phases were combined, dried over MgSO4, concentrated in vacuo and purified by flash chromatography (silica gel, 0% to 100% ethyl acetate in heptane) to give the title compound after a crystallization step from heptane (4.47 g, 59%) as white crystalline solid; LC-MS (UV peak area, ESI) 100%, 239.1514 (MH+).

1. customto give a light brown solution
2. temperatureat reflux temperature
3. temperaturethe mixture heated for another 2 h
4. stirringthe reaction was stirred overnight
5. concentrationThe mixture was concentrated in vacuo
6. customthe residue was partitioned between ethyl acetate (200 mL, 2×150 mL) and sodium bicarbonate solution (2 M, 100 mL)
7. dry with materialdried over MgSO4
8. concentrationconcentrated in vacuo
9. custompurified by flash chromatography (silica gel, 0% to 100% ethyl acetate in heptane)

ORD-Eintrag

ord-6ccaac9caeb3483db2288628637e514e

Quelldatensatz

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09334268B2