1-(1-Piperidinylcarbonyl)piperazine → 2-[4-(Piperidine-1-carbonyl)piperazin-1-yl]-5,6,7,8-tetrahydro-3H-quinazolin-4-one

HRID 523486

Reaktionsgleichung

Reaktionsgleichung von HRID 523486
CS[C:3]1[NH:12][C:11](=[O:13])[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1.[N:14]1([C:20]([N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)=[O:21])[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(O)CC(C)C.C(#N)C>[N:22]1([C:20]([N:14]2[CH2:15][CH2:16][N:17]([C:3]3[NH:12][C:11](=[O:13])[C:10]4[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=4[N:4]=3)[CH2:18][CH2:19]2)=[O:21])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1

Komponenten

5

Edukt 2

HCID 10950151-(1-Piperidinylcarbonyl)piperazine2×HCID 1354352562-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Produkt 1

HCID 1362683422-[4-(Piperidine-1-carbonyl)piperazin-1-yl]-5,6,7,8-tetrahydro-3H-quinazolin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6342AcetonitrileLösungsmittelHCID 31260Isoamyl AlcoholLösungsmittel2×

Versuchsvorschrift

2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol) and piperazin-1-ylpiperidin-1-ylmethanone (100.5 mg; 0.51 mmol) are reacted in isoamyl alcohol (1 ml) in accordance with the procedure for Example 1. After a reaction time of 4 h, piperazin-1-ylpiperidin-1-ylmethanone (50.3 mg; 0.26 mmol) and isoamyl alcohol (0.5 ml) are again added, and the mixture is again irradiated in the microwave for 4 h. The crystals obtained after conventional work-up are dissolved in acetonitrile and water and freeze-dried; yield: 17 mg (9%), crystals;

Aufarbeitung

  1. customthe mixture is again irradiated in the microwave for 4 h
  2. customThe crystals obtained after conventional work-up
  3. dry with materialwater and freeze-dried

Quellen und Nachweise

ORD-Eintrag
ord-b6969258110b4179bb87e069ddf3fd81
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09339503B2

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