Hydrochloric Acid → 2-(2-(Trifluoromethyl) pyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexan-3-one

HRID 523584Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 523584
[O:1]=[C:2]1[N:7]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[CH:6]2[CH:4]([CH2:5]2)[N:3]1C(OCC1C=CC=CC=1)=O.Cl>>[F:17][C:14]([F:15])([F:16])[C:10]1[CH:9]=[C:8]([N:7]2[C:2](=[O:1])[NH:3][CH:4]3[CH:6]2[CH2:5]3)[CH:13]=[CH:12][N:11]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 70982114Benzyl 3-oxo-4-(2-(trifluoromethyl)pyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexane-2-carboxylate

Produkt 1

HCID 709831402-(2-(Trifluoromethyl) pyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexan-3-oneAusbeute 112,8 %

Versuchsvorschrift

Using analogous reagents and reaction conditions as described in Example 30 for the preparation of I-30c, benzyl 3-oxo-4-(2-(trifluoromethyl)pyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexane-2-carboxylate (I-32a: 55 mg, 0.1458 mmol) was treated with 4.0 mL of 6N HCl to yield the 40 mg of the product (85% yield).

Aufarbeitung

  1. customreagents and reaction conditions

Quellen und Nachweise

ORD-Eintrag
ord-a875fe3ede464eef9a999423ee68acc9
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09339501B2

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