Ethyl Acetate → HCID 70981944, Verbindung

HRID 523591Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 523591
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[CH2:12][CH2:11][CH2:10][CH:9]=1.C(OCC)(=O)C>C1(C)C=CC=CC=1.CCCCCC.[Pt]=O>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1

Komponenten

6

Edukt 2

HCID 8857Ethyl AcetateHCID 709821203-Bromo-4-cyclopent-1-enyl-pyridine

Produkt 1

HCID 70981944HCID 70981944, VerbindungAusbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 82844Platinum oxide (PtO)KatalysatorHCID 1140TolueneLösungsmittelHCID 8058HexaneLösungsmittel

Versuchsvorschrift

Platinum oxide (20 mg) was added to a mixture of 3-bromo-4-cyclopent-1-enyl-pyridine (I-34b: 140 mg, 0.622 mmol) in toluene (5 mL) and stirred overnight under hydrogen atmosphere. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered through celite pad and washed with toluene and concentrated to afford crude product. Purification by column chromatography (8% ethyl acetate in hexane) afforded 98 mg of the product (71% yield).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite pad
  2. washwashed with toluene
  3. concentrationconcentrated
  4. customto afford crude product
  5. customPurification by column chromatography (8% ethyl acetate in hexane)

Quellen und Nachweise

ORD-Eintrag
ord-d3eeadd28e1747978832e2646d230272
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09339501B2

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