(2-Amino-5-bromo-3-fluorophenyl)methanol → 2-Amino-5-bromo-3-fluorobenzaldehyde

HRID 524078

Reaktionsgleichung

Reaktionsgleichung von HRID 524078
[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+2]>[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

Komponenten

4

Edukt 1

HCID 54312525(2-Amino-5-bromo-3-fluorophenyl)methanol

Produkt 1

HCID 542514502-Amino-5-bromo-3-fluorobenzaldehydeAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 160959Manganese oxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of (2-amino-5-bromo-3-fluorophenyl)methanol (13 g, 59.4 mmol) and manganese oxide (31 g, 356.4 mmol) in dichloromethane (400 mL) was stirred at RT overnight. TLC showed the starting material consumed completely. The solid was filtered off, and the filtrate was concentrated to give the title compound (11 g, 85%) as a light yellow solid, which was directly used in the next step without further purification.

Aufarbeitung

  1. customconsumed completely
  2. filtrationThe solid was filtered off
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-b97d07b899804540be38b71d5efebbd3
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09340514B2

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