2-Cyanobenzenesulfonyl Chloride → 2-({4-[3-(3,4-Dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}sulfonyl)benzonitrile

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Cyanobenzenesulfonyl Chloride	HCID 522347	—
Edukt	5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride	HCID 66616406	—
Produkt	2-({4-[3-(3,4-Dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}sulfonyl)benzonitrile	HCID 49870390	—

Reaktionsschritte

The title compound is prepared analogously as described for GP1 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B1*HCl) and 2-cyanobenzenesulfonyl chloride as starting compounds. The crude product is purified by crystallization from EA and diethyl ether to yield the title compound.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09340522B2
Quelldatensatz	uspto-grants-2016_05
ORD ID	ord-fe3a9e57902a4feb932d7bc70cb15d7a
Quellennotiz	uspto-grants-2016_05