1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine → 5-(7-Methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one

HRID 524297

Reaktionsgleichung

Reaktionsgleichung von HRID 524297
[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[C:6]([C:14]2[C:15]([CH3:21])([CH3:20])[C:16](=[O:19])[NH:17][N:18]=2)=[CH:5][CH:4]=1.CC1C=CC(S(O[CH:33]2[CH2:38][CH2:37][N:36](C(OC(C)(C)C)=O)[CH2:35][CH2:34]2)(=O)=O)=CC=1>>[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[C:6]([C:14]2[C:15]([CH3:21])([CH3:20])[C:16](=[O:19])[N:17]([CH:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)[N:18]=2)=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 157347131-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine2×HCID 666165895-(7-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one2×

Produkt 1

HCID 666165915-(7-Methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one

Versuchsvorschrift

Prepared analogously as described for the example B1 (Alternative 1) using 5-(7-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (compound C5) and tert-butyl 4-{[(4-methylphenyl)sulfonyl]oxy}piperidine-1-carboxylate (compound E1) as starting compounds resulting in the hydrochloride salt of the title compound. (compound B5*HCl)

Aufarbeitung

  1. customPrepared analogously

Quellen und Nachweise

ORD-Eintrag
ord-9833391843a8495b96ada534e8d3080b
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09340522B2

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