HCID 19963711, Verbindung → HCID 19963713, Verbindung

HRID 52438Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 52438
[CH3:1][C:2]1([CH3:19])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[C:13][Si](C)(C)C)[CH:10]=2)[NH:5][C:4](=[O:18])[CH2:3]1>CO>[CH3:1][C:2]1([CH3:19])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[CH:13])[CH:10]=2)[NH:5][C:4](=[O:18])[CH2:3]1

Komponenten

3

Edukt 1

HCID 19963711HCID 19963711, Verbindung2×

Produkt 1

HCID 19963713HCID 19963713, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2.64 g (9.7 mmol) of 4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-6[(trimethylsilyl)ethynyl]quinoline (Compound 2) in 200 ml of methanol was added 0.269 g (1.95 mmol) of K2CO3The reaction was stirred at room temperature for 12 h. The reaction was then concentrated in vacuo and water was added to the residue. The aqueous layer was extracted with methylene chloride (2×). The organic layers were dried (MgSO4), filtered and concentrated in vacuo to give the title compound as a white solid.

Aufarbeitung

  1. concentrationThe reaction was then concentrated in vacuo and water
  2. additionwas added to the residue
  3. extractionThe aqueous layer was extracted with methylene chloride (2×)
  4. dry with materialThe organic layers were dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-30f595256a6247b692fae42f1712eea2
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616712

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