Hydrochloric Acid → 3-Bromo-4-chloro-5-fluoropyridine hydrochloride

HRID 524883Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 524883
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[Cl:8].Cl>CCCCC>[ClH:8].[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[Cl:8]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 709772193-Bromo-4-chloro-5-fluoropyridine

Produkt 1

HCID 867209403-Bromo-4-chloro-5-fluoropyridine hydrochlorideAusbeute 120,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8003PentaneLösungsmittel

Versuchsvorschrift

To a solution of 3-bromo-4-chloro-5-fluoro-pyridine (7.56 g, 32.18 mmol) in pentane (100 mL) was added hydrogen chloride (2M in ether) (17.7 mL of 2 M, 35.4 mmol). An off-white precipitate formed instantly. The mixture was stirred for 5 minutes then the solid was collected by filtration, washed with pentane and dried by suction to afford the desired product as an off-white solid (4.79 g, 60%). 1H NMR (DMSO-d6) δ 8.77 (s, 1H), 8.75 (s, 1H).

Aufarbeitung

  1. customAn off-white precipitate formed instantly
  2. filtrationthe solid was collected by filtration
  3. washwashed with pentane
  4. customdried by suction

Quellen und Nachweise

ORD-Eintrag
ord-c8dea6efc6e74c3a9f924dc42fb3f8c6
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09340546B2

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