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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 524978Erstellt: 24. Oktober 2026

2-(((Tert-butoxy)carbonyl)amino)butanoic acid → tert-Butyl 1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate

https://huagongshe.com/de/reaction/524978

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt2-(((Tert-butoxy)carbonyl)amino)butanoic acidHCID 333522—
Edukt1-amino-N-phenyl-1H-pyrrole-2-carboxamideHCID 70922454—
LösungsmittelDiethyl EtherHCID 3283—
Produkttert-Butyl 1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamateHCID 7092214387,6%

Reaktionsschritte

The title compound was prepared following the experimental procedure described in preparation 20a from 1.50 g (7.45 mmol) of 1-amino-N-phenyl-1H-pyrrole-2-carboxamide and 1.82 g (8.95 mmol) of racemic 2-(tert-butoxycarbonylamino)butanoic acid (purchased from ABCR, cat. no. AB154485). After recristallysation of the crude product in diethylether, 2.43 g (84% yield) of the title compound were obtained.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS09340547B2
Quelldatensatzuspto-grants-2016_05
ORD IDord-2c32fb8c08414f52acc2d661f579da4b
Quellennotizuspto-grants-2016_05