Hydrochloric Acid → tert-Butyl (2S)-1-(3-bromo-2-(tetrahydro-2H-pyran-3-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate

HRID 525011

Reaktionsgleichung

Reaktionsgleichung von HRID 525011
[Br:1][C:2]1[CH:6]=[CH:5][N:4]([NH:7][C:8](=[O:19])[C@@H:9]([NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH3:10])[C:3]=1[C:20]([O:22]C)=O.[O:24]1[CH2:29][CH2:28][CH2:27][CH:26]([NH2:30])[CH2:25]1.Cl>>[Br:1][C:2]1[CH:6]=[CH:5][N:4]([NH:7][C:8](=[O:19])[C@@H:9]([NH:11][C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH3:10])[C:3]=1[C:20](=[O:22])[NH:30][CH:26]1[CH2:27][CH2:28][CH2:29][O:24][CH2:25]1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 5200320Oxan-3-amineHCID 86722018(S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate

Produkt 1

HCID 86722031tert-Butyl (2S)-1-(3-bromo-2-(tetrahydro-2H-pyran-3-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate

Versuchsvorschrift

Same procedure as described in preparation 137a was used from (S)-methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (4.00 g, 10.25 mmols) and tetrahydro-2H-pyran-3-amine.HCl (2.12 g, 15.41 mmols). The title compound was obtained (2.24 g, 48%).

Quellen und Nachweise

ORD-Eintrag
ord-52f7600c7e394685a44a0e1f1d0d7335
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09340547B2

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