Methanol → Methyl 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

HRID 525468

Reaktionsgleichung

Reaktionsgleichung von HRID 525468
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([C:12]([OH:14])=[O:13])[CH2:6][CH2:5]2.[CH3:15]O.S(=O)(=O)(O)O>>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([C:12]([O:14][CH3:15])=[O:13])[CH2:6][CH2:5]2

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 190700016-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Produkt 1

HCID 58055117Methyl 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylateAusbeute 100 %

Versuchsvorschrift

To a solution of 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (0.5 g, 3 mmol) in methanol (6 mL, 200 mmol) was added sulfuric acid (0.05 g, 0.5 mmol) and stirred over weekend. After concentration, the residue was dissolved in EtOAc and washed with water, brine and dried over Na2SO4 to give the pure product as a white solid (0.55 g, 100%). LCMS: Rt=1.17 min, m/z=207.00 [M+], 100%.

Aufarbeitung

  1. concentrationAfter concentration
  2. dissolutionthe residue was dissolved in EtOAc
  3. washwashed with water, brine
  4. dry with materialdried over Na2SO4

Quellen und Nachweise

ORD-Eintrag
ord-a7e6033a74cc4ee7948069f4f9150761
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09340527B2

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