Hydrochloric Acid → trans-3-Amino-4-methoxypyrrolidine dihydrochloride

HRID 525757Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 525757
[ClH:1].[NH2:2][C@H:3]1[C@H:7]([O:8][CH3:9])[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.Cl.CCO>>[ClH:1].[ClH:1].[CH3:9][O:8][C@@H:7]1[CH2:6][NH:5][CH2:4][C@H:3]1[NH2:2]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 89906581rac-tert-butyl (3R,4R)-3-amino-4-methoxypyrrolidine-1-carboxylate hydrochloride

Produkt 1

HCID 67925434trans-3-Amino-4-methoxypyrrolidine dihydrochloride

Versuchsvorschrift

A mixture of (trans)-tert-butyl 3-amino-4-methoxypyrrolidine-1-carboxylate hydrochloride (0.5 g, 1.939 mmol) and HCl in EtOH (15.51 mL, 19.39 mmol) was stirred at RT for 24 h. The solvent was evaporated off under reduced pressure to give the title compound.

Aufarbeitung

  1. customThe solvent was evaporated off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-84f24c5cc7c54af8a3e6cfe8c58b6d4e
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09340537B2

Notizen zur Reaktion

Wird geladen…