Reaktionsgleichung
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH:12]=[CH:11][C:10](=[O:13])[N:9]([C:14]3[CH:15]=[C:16]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH:17]=[CH:18][CH:19]=3)[C:7]=2[N:8]=1.[C:28](OC)(=O)[CH2:29]CC.C(C1C(NC2C=C(NC(=O)OC(C)(C)C)C=CC=2)=NC(SC)=NC=1)=O>>[CH2:28]([C:11]1[C:10](=[O:13])[N:9]([C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:24])([CH3:26])[CH3:25])[CH:17]=[CH:18][CH:19]=2)[C:7]2[N:8]=[C:3]([S:2][CH3:1])[N:4]=[CH:5][C:6]=2[CH:12]=1)[CH3:29]Komponenten
4
Versuchsvorschrift
This compound (720 mg, 1.75 mmol, 31% yield) obtained as an off-white solid was prepared according to procedure described for Intermediate 51, using methyl butanoate (1.89 mL, 16.65 mmol) and tert-butyl (3-((5-formyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate (50) (2.00 g, 5.55 mmol) as the starting materials. m/z (ESI, +ve ion) 413.0 (M+1)+. 1H NMR (400 MHz, CDCl3) δ ppm 8.62 (1H, s), 7.47-7.55 (2H, m), 7.39-7.46 (1H, m), 7.29 (1H, d, J=1.4 Hz), 6.92 (1H, dd, J=7.8, 1.0 Hz), 6.57 (1H, br. s.), 2.66 (2H, q, J=7.4 Hz), 2.19 (3H, s), 1.50 (9H, s), 1.23-1.31 (3H, m).
Aufarbeitung
- customwas prepared
Quellen und Nachweise
- ORD-Eintrag
- ord-2f59fcf310ab4ce48a4058e07a11e904
- Quelldatensatz
- uspto-grants-2016_05
- Patentnummer
- US09346801B2
Verknüpfte Notizen
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