Stannous chloride dihydrate → 6-[(3-Ethyl-1,2-benzisoxazol-4-yl)oxy]-3-pyridinamine

HRID 527528Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 527528
[CH2:1]([C:3]1[C:7]2[C:8]([O:12][C:13]3[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][N:14]=3)=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][N:4]=1)[CH3:2].O.O.[Sn](Cl)Cl>C(O)C>[CH2:1]([C:3]1[C:7]2[C:8]([O:12][C:13]3[N:14]=[CH:15][C:16]([NH2:19])=[CH:17][CH:18]=3)=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][N:4]=1)[CH3:2]

Komponenten

4

Edukt 2

HCID 61436Stannous chloride dihydrateHCID 679599933-Ethyl-4-[(5-nitro-2-pyridinyl)oxy]-1,2-benzisoxazole2×

Produkt 1

HCID 679605196-[(3-Ethyl-1,2-benzisoxazol-4-yl)oxy]-3-pyridinamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

3-ethyl-4-[(5-nitro-2-pyridinyl)oxy]-1,2-benzisoxazole (Intermediate 32, 9 mg) was dissolved in 3.0 ml of ethanol. Then tin(II) chloride dihydrate (21.4 mg, 0.095 mmol) was added and the reaction mixture was stirred at 80° C. for 3 hours. After quenching with water and extraction with ethyl acetate, the organic phase was dried over sodium sulphate, filtered and evaporated to afford the title compound.

Aufarbeitung

  1. customAfter quenching with water and extraction with ethyl acetate
  2. dry with materialthe organic phase was dried over sodium sulphate
  3. filtrationfiltered
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-c13be8d01eee4b52a91eb1aa757d30bb
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346790B2

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