Hydrochloric Acid → 1-(2,6-Dihydroxyphenyl)-2-methyl-1-propanone

HRID 527532Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 527532
COC[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11]COC)[C:6]=1[C:15](=[O:19])[CH:16]([CH3:18])[CH3:17].Cl>CO>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[C:6]=1[C:15](=[O:19])[CH:16]([CH3:17])[CH3:18]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 679585761-(2,6-Bis{[(methyloxy)methyl]oxy}phenyl)-2-methyl-1-propanone2×

Produkt 1

HCID 134833211-(2,6-Dihydroxyphenyl)-2-methyl-1-propanoneAusbeute 86,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1-(2,6-bis{[(methyloxy)methyl]oxy}phenyl)-2-methyl-1-propanone (Intermediate 36, 1.58 g, 5.89 mmol) was dissolved in methanol (40.0 ml) and an aqueous solution of HCl (23.6 mL of a 2M aqueous solution, 47.1 mmol) was added. The reaction mixture was refluxed for 1 hour. After quenching with water, the reaction mixture was extracted with ethyl acetate. The gathered organic layers were dried over sodium sulphate, filtered and evaporated to afford the title compound (916 mg).

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed for 1 hour
  2. customAfter quenching with water
  3. extractionthe reaction mixture was extracted with ethyl acetate
  4. dry with materialThe gathered organic layers were dried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-cd3b80daa5fa4eb7989f5606870afe0e
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346790B2

Notizen zur Reaktion

Wird geladen…