Benzene, 2-methoxy-1-methyl-4-nitro- → 3-Methoxy-4-methylaniline

HRID 527719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 527719
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[O:11][CH3:12]>CO>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[O:11][CH3:12]

Komponenten

3

Edukt 1

HCID 83159Benzene, 2-methoxy-1-methyl-4-nitro-

Produkt 1

HCID 278823-Methoxy-4-methylanilineAusbeute 90,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1-methyl-2-(methyloxy)-4-nitrobenzene (2.5 g, 14.96 mmol) in methanol (50 mL) Ni-Raney (˜2 g) was added and the reaction mixture was stirred overnight at room temperature under H2 atmosphere (1 atm). The catalyst was filtered off and the residue was purified by SCX cartridge (50 g) to afford the title compound (1.86 g) as a colourless oil.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. customthe residue was purified by SCX cartridge (50 g)

Quellen und Nachweise

ORD-Eintrag
ord-f265de6e7e6f4015b51a458380e9583b
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346790B2

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