Hydrochloric Acid → 6-Amino-9-[3-(1-azetidinyl)propyl]-2-(butyloxy)-7,9-dihydro-8H-purin-8-one

HRID 527832Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 527832
[N:1]1([CH2:5][CH2:6][CH2:7][N:8]2[C:16]([O:17]C)=[N:15][C:14]3[C:9]2=[N:10][C:11]([O:20][CH2:21][CH2:22][CH2:23][CH3:24])=[N:12][C:13]=3[NH2:19])[CH2:4][CH2:3][CH2:2]1.Cl.O1CCOCC1>CO>[NH2:19][C:13]1[N:12]=[C:11]([O:20][CH2:21][CH2:22][CH2:23][CH3:24])[N:10]=[C:9]2[C:14]=1[NH:15][C:16](=[O:17])[N:8]2[CH2:7][CH2:6][CH2:5][N:1]1[CH2:2][CH2:3][CH2:4]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 592526009-[3-(1-Azetidinyl)propyl]-2-(butyloxy)-8-(methyloxy)-9H-purin-6-amine

Produkt 1

HCID 592526036-Amino-9-[3-(1-azetidinyl)propyl]-2-(butyloxy)-7,9-dihydro-8H-purin-8-oneAusbeute 104 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

9-[3-(1-Azetidinyl)propyl]-2-(butyloxy)-8-(methyloxy)-9H-purin-6-amine (13 mg, 0.039 mmol) was dissolved in methanol (3 ml) and 4M hydrogen chloride in 1,4-dioxane (0.243 ml, 0.972 mmol) was added and the mixture stirred at room temperature for 18 hours. The solvent was removed in vacuo and the residue was dissolved in methanol and loaded onto an aminopropyl SPE cartridge (2 g). The cartridge was eluted with methanol and the solvent removed to give the title compound as a white solid (13 mg).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in methanol
  3. washThe cartridge was eluted with methanol
  4. customthe solvent removed

Quellen und Nachweise

ORD-Eintrag
ord-4947b0f385fa4eec85407c3a4d18f5b6
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346806B2

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