Benzenesulfonyl chloride → 4-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

To a solution of 4-bromo-7H-pyrrolo[2,3-d]pyrimidine (2.5 g, 12.62 mmol) in 50 mL N,N-dimethylformamide at 0° C. was added 95% sodium hydride (0.351 g, 13.89 mmol). The mixture was stirred at 0° C. for 30 minutes, benzenesulfonyl chloride (1.772 mL, 13.89 mmol) was added, and the mixture was stirred at 0° C. for an additional 2 hours. The mixture was quenched with 20 mL saturated ammonium chloride and diluted with water (100 mL). The resulting suspension was stirred for 5 minutes, filtered, and dried under-vacuum to give the title compound. MS (ESI+) m/z 340.0 (M+H)+.

1. stirringthe mixture was stirred at 0° C. for an additional 2 hours
2. customThe mixture was quenched with 20 mL saturated ammonium chloride
3. additiondiluted with water (100 mL)
4. stirringThe resulting suspension was stirred for 5 minutes
5. filtrationfiltered
6. customdried under-vacuum

ORD-Eintrag

ord-bbb9ead34179480c8fd333bb1d516ccc

Quelldatensatz

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09346813B2