p-Toluenesulfonic acid monohydrate → HCID 89704942, Verbindung
Reaktionsgleichung
[C:1]([C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8](=[O:26])[CH2:9][NH:10][C:11]([CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1)=[O:12])#[N:2].O.CC1C=CC(S(O)(=O)=O)=CC=1>C(#N)C>[C:1]([C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8](=[O:26])[CH2:9][NH:10][C:11]([CH:13]1[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]1)=[O:12])#[N:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of (S)-tert-butyl 4-(2-(2-cyanopyrrolidine-1-yl)-2-oxoethylcarbamoyl)piperidine-1-carboxylate (0.100 g, 0.274 mmol) in 2 ml Acetonitrile was 4-methylbenzenesulfonic acid hydrate (0.073 g, 0.384 mmol) added and the mixture was stirred for 24 h. After evaporation of the volatiles, the sample was purified by preparative HPLC to yield an reddish oil.