Hydrochloric Acid → Hydrochloric Acid

HRID 528711Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 528711
C(OC([N:8]1[CH2:28][CH2:27][C:12]2=[C:13]([N:20]3[CH2:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:14]3[C:18]([N:19]=[C:11]2[CH2:10][CH2:9]1)=[CH:17][CH:16]=[N:15]3)=O)(C)(C)C.[ClH:29]>C(Cl)Cl.O1CCOCC1>[O:23]1[CH2:24][CH2:25][CH2:26][N:20]([C:13]2[N:14]3[C:18]([N:19]=[C:11]4[CH2:10][CH2:9][NH:8][CH2:28][CH2:27][C:12]=24)=[CH:17][CH:16]=[N:15]3)[CH2:21][CH2:22]1.[ClH:29]

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 6797938810-[1,4]Oxazepan-4-yl-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester

Produkt 2

HCID 313Hydrochloric AcidHCID 6745769810-[1,4]Oxazepan-4-yl-6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To 88 mg (0.23 mmol) 10-[1,4]oxazepan-4-yl-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester in 3 mL DCM, was added 1.13 mL (4.5 mmol) HCl in dioxane (4 M), and the reaction was stirred at room temperature for 16 hours. The solvent was evaporated to give the desired product as a HCl salt.

Aufarbeitung

  1. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-239ee4685529420a835d4895f16f8cae
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346816B2

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