Trifluoroacetic acid → 3-Benzothiazol-2-yl-azetidine trifluoroacetate

HRID 528739Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 528739
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[S:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)[CH2:9]1)=O)(C)(C)C.[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>C(Cl)Cl>[F:24][C:23]([F:26])([F:25])[C:21]([OH:27])=[O:22].[S:13]1[C:14]2[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=[C:12]1[CH:10]1[CH2:9][NH:8][CH2:11]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 442398183-Benzothiazol-2-yl-azetidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 674587613-Benzothiazol-2-yl-azetidine trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To 48 mg (166 μmol) 3-benzothiazol-2-yl-azetidine-1-carboxylic acid tert-butyl ester was added 5 mL DCM and 5 mL TFA. The resulting mixture was stirred at room temperature for 30 minutes. The solvent was evaporated to give the product as the TFA salt which was used in the next step without further purification.

Aufarbeitung

  1. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-f3496f97b59944cf94bf5c815d221f4b
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346816B2

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