Trifluoroacetic acid → 3-Ethynyl-pyrrolidinium trifluoro-acetate

HRID 528776Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 528776
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]#[CH:14])[CH2:9]1)=O)(C)(C)C.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[F:18][C:17]([F:20])([F:19])[C:15]([O-:21])=[O:16].[C:13]([CH:10]1[CH2:11][CH2:12][NH2+:8][CH2:9]1)#[CH:14]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 54012212tert-Butyl 3-ethynylpyrrolidine-1-carboxylate

Produkt 1

HCID 866671763-Ethynyl-pyrrolidinium trifluoro-acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To 0.85 g (4.35 mmol) 3-Ethynyl-pyrrolidine-1-carboxylic acid tert-butyl ester in 30 mL DCM was added 2 mL (26.0 mmol) TFA and stirring was continued at room temperature for 3 h. The solvents were evaporated and the residue was used for the next step without further purification.

Aufarbeitung

  1. customThe solvents were evaporated
  2. customthe residue was used for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c1eb13ada4284922a86903b907fe8526
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346816B2

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