Methanol → (3-Ethynyl-pyrrolidin-1-yl)-[1-(6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]inden-10-yl)-azetidin-3-yl]-methanone

HRID 528778Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 528778
C(OC([N:8]1[CH2:34][CH2:33][C:12]2=[C:13]([N:20]3[CH2:23][CH:22]([C:24]([N:26]4[CH2:30][CH2:29][CH:28]([C:31]#[CH:32])[CH2:27]4)=[O:25])[CH2:21]3)[N:14]3[C:18]([N:19]=[C:11]2[CH2:10][CH2:9]1)=[CH:17][CH:16]=[N:15]3)=O)(C)(C)C.C(O)(C(F)(F)F)=O.CO>C(Cl)Cl>[C:31]([CH:28]1[CH2:29][CH2:30][N:26]([C:24]([CH:22]2[CH2:21][N:20]([C:13]3[N:14]4[C:18]([N:19]=[C:11]5[CH2:10][CH2:9][NH:8][CH2:34][CH2:33][C:12]=35)=[CH:17][CH:16]=[N:15]4)[CH2:23]2)=[O:25])[CH2:27]1)#[CH:32]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 6422Trifluoroacetic acidHCID 8666717710-[3-(3-Ethynyl-pyrrolidine-1-carbonyl)-azetidin-1-yl]-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohept[f]indene-7-carboxylic acid tert-butyl ester

Produkt 1

HCID 86667178(3-Ethynyl-pyrrolidin-1-yl)-[1-(6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]inden-10-yl)-azetidin-3-yl]-methanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To 36 mg (0.08 mmol) 10-[3-(3-Ethynyl-pyrrolidine-1-carbonyl)-azetidin-1-yl]-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohept[f]indene-7-carboxylic acid tert-butyl ester in 10 mL DCM was added 0.4 mL TFA and stirring was continued for 3 h at room temperature. After addition of 2 mL of MeOH 2M NaOH added drop wise to neutralize the reaction mixture. The solvents were evaporated and the residue was purified by HPLC.

Aufarbeitung

  1. customThe solvents were evaporated
  2. customthe residue was purified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-a5b2761bf08f4bd2baff370e40231e0b
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346816B2

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