Hydrochloric Acid → 4,4-Difluoro-perhydro-azepinium chloride

HRID 528780Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 528780
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][C:11]([F:16])([F:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:17]>>[Cl-:17].[F:15][C:11]1([F:16])[CH2:12][CH2:13][CH2:14][NH2+:8][CH2:9][CH2:10]1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 58110242Tert-butyl 4,4-difluoroazepane-1-carboxylate

Produkt 1

HCID 674556284,4-Difluoro-perhydro-azepinium chloride

Versuchsvorschrift

To 830 mg (3.53 mmol) of 4,4-Difluoro-perhydro-azepine-1-carboxylic acid tert-butyl ester was added 5 mL of 2 M aq. HCl and stirring was continued overnight at room temperature. The reaction mixture was freeze dried and used for the next step without further purification

Aufarbeitung

  1. customdried
  2. customused for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-e2a839af5d554d9aadeda1c107cbe790
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346816B2

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