1-(3-Chloropropyl)-pyrrolidine → 7-(3-(Pyrrolidin-1-yl)propoxy)naphthalene-2-sulfonic acid
Reaktionsgleichung
[O-:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([S:12]([O-:15])(=[O:14])=[O:13])=[CH:9]2)=[CH:4][CH:3]=1.[Na+].[Na+].Cl[CH2:19][CH2:20][CH2:21][N:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1>>[N:22]1([CH2:21][CH2:20][CH2:19][O:1][C:2]2[CH:11]=[C:10]3[C:5]([CH:6]=[CH:7][C:8]([S:12]([OH:15])(=[O:13])=[O:14])=[CH:9]3)=[CH:4][CH:3]=2)[CH2:26][CH2:25][CH2:24][CH2:23]1Komponenten
3
Versuchsvorschrift
Following a procedure analogous to that for the synthesis of Intermediate 26B, sodium 7-oxidonaphthalene-2-sulfonate (Pfaltz and Bauer, 200 mg, 0.75 mmol) and 1-(3-chloropropyl)pyrrolidine (110 mg, 0.75 mmol) were converted to the title compound (138 mg, 55%). MS(ESI+) m/z 336.1 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-540d707212b54688b1158e05a96daf45
- Quelldatensatz
- uspto-grants-2016_05
- DOI