1-Benzyl 3-ethyl 4-fluoroisophthalate → 1-Benzyl 3-ethyl 4-(4-chloro-3-(dipropylamino)-5-(trifluoromethyl)-1H-pyrazol-1-yl)isophthalate

HRID 528960Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 528960
[Cl:1][C:2]1[C:3]([N:11]([CH2:15][CH2:16][CH3:17])[CH2:12][CH2:13][CH3:14])=[N:4][NH:5][C:6]=1[C:7]([F:10])([F:9])[F:8].F[C:19]1[CH:34]=[CH:33][C:22]([C:23]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:24])=[CH:21][C:20]=1[C:35]([O:37][CH2:38][CH3:39])=[O:36]>>[Cl:1][C:2]1[C:3]([N:11]([CH2:15][CH2:16][CH3:17])[CH2:12][CH2:13][CH3:14])=[N:4][N:5]([C:19]2[CH:34]=[CH:33][C:22]([C:23]([O:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[O:24])=[CH:21][C:20]=2[C:35]([O:37][CH2:38][CH3:39])=[O:36])[C:6]=1[C:7]([F:9])([F:8])[F:10]

Komponenten

3

Edukt 2

HCID 710609931-Benzyl 3-ethyl 4-fluoroisophthalate2×HCID 710622264-chloro-N,N-dipropyl-5-(trifluoromethyl)-1H-pyrazol-3-amine

Produkt 1

HCID 710622401-Benzyl 3-ethyl 4-(4-chloro-3-(dipropylamino)-5-(trifluoromethyl)-1H-pyrazol-1-yl)isophthalateAusbeute 47 %

Versuchsvorschrift

Following a procedure analogous to that for the synthesis of Intermediate 1E, 4-chloro-N,N-dipropyl-5-(trifluoromethyl)-1H-pyrazol-3-amine (287 mg, 1.06 mmol) and 1-benzyl 3-ethyl 4-fluoroisophthalate (Intermediate 91B, 268 mg, 0.89 mmol) were converted to the title compound (231 mg, 47%). MS(ESI+) m/z 552.3 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-b4a69970f8ce41f3b93444760049d14f
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346795B2

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