HCID 71062377, Verbindung → HCID 71060740, Verbindung
Reaktionsgleichung
[CH2:1]([N:5]([CH2:33][CH2:34][CH2:35][CH3:36])C1N=C(C2C=CC(C(O)=O)=CC=2C(N2CCC3C(=CC=CC=3)C2)=O)C=CN=1)[CH2:2][CH2:3][CH3:4].Cl[C:38]1[N:43]=[C:42]([C:44]2[CH:53]=[CH:52][C:47]([C:48]([O:50]C)=[O:49])=[CH:46][C:45]=2[C:54]([O:56][C:57]([CH3:60])([CH3:59])[CH3:58])=[O:55])[CH:41]=[CH:40][N:39]=1>>[C:57]([O:56][C:54]([C:45]1[CH:46]=[C:47]([CH:52]=[CH:53][C:44]=1[C:42]1[CH:41]=[CH:40][N:39]=[C:38]([N:5]([CH2:33][CH2:34][CH2:35][CH3:36])[CH2:1][CH2:2][CH2:3][CH3:4])[N:43]=1)[C:48]([OH:50])=[O:49])=[O:55])([CH3:58])([CH3:59])[CH3:60]Komponenten
3
Versuchsvorschrift
Following a procedure analogous to that for the synthesis of Intermediate 291B, 3-tert-butyl 1-methyl 4-(2-chloropyrimidin-4-yl)isophthalate (244 mg, 0.70 mmol) was converted to the title compound (210 mg, 70% for two steps). MS(ESI+) m/z 428.2 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-79770d2eced94734a5e322f4c2649737
- Quelldatensatz
- uspto-grants-2016_05