(2S)-2-(((tert-butoxy)carbonyl)amino)hex-5-enoic acid → (7S,11aR,Z)-7-Amino-3,4,7,8,9,11a-hexahydro-1H-pyrido[1,2-a]azocin-6(2H)-one hydrochloride
Reaktionsgleichung
[ClH:1].[NH2:2][C@@H:3]1[C:9](=[O:10])[N:8]2[CH2:11][CH2:12][CH2:13][CH2:14][C@@H:7]2[CH:6]=[CH:5][CH2:4]1.[C:15](OC(N[C@@H](CCC=C)C(O)=O)=O)(C)(C)C>>[ClH:1].[NH2:2][C@@H:3]1[C:9](=[O:10])[N:8]2[CH2:11][CH2:12][CH2:13][CH2:14][C@@H:7]2[CH:6]=[CH:5][CH2:4][CH2:15]1Komponenten
3
Versuchsvorschrift
(7S,11aR,Z)-7-Amino-3,4,7,8,9,11a-hexahydro-1H-pyrido[1,2-a]azocin-6(2H)-one hydrochloride (538 mg, 2.332 mmol) was synthesized as described for the preparation of Intermediate 53 using (S)-2-(tert-butoxycarbonylamino)hex-5-enoic acid in step E. Anal. Calcd. for C11H18N2O m/z 194.2. found: 195.0 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag