Ethanol → Ethyl 5-ethoxy-1H-pyrazole-3-carboxylate

HRID 529968

Reaktionsgleichung

Reaktionsgleichung von HRID 529968
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][C:6](=O)[C:7](Cl)(Cl)Cl)[CH3:2].[NH2:13][NH2:14].Cl.[CH3:16][CH2:17][OH:18]>>[CH2:1]([O:3][C:4]([C:5]1[NH:13][N:14]=[C:7]([O:18][CH2:17][CH3:16])[CH:6]=1)=[O:12])[CH3:2]

Komponenten

4

Edukt 3

HCID 702EthanolHCID 77294Ethyl 4,4,4-trichloro-3-oxobutyrateHCID 115031Hydrazinium chloride

Produkt 1

HCID 68571888Ethyl 5-ethoxy-1H-pyrazole-3-carboxylate

Versuchsvorschrift

4,4,4-Trichloro-3-oxo-butyric acid ethyl ester (Int 8, 1 eq) and H2NNH2.HCl (1.1 eq) are mixed in EtOH. The resulting mixture is refluxed overnight. The mixture is then evaporated and the obtained crude is purified by chromatography to give Int 9 and 5-ethoxy-2H-pyrazole-3-carboxylic acid ethyl ester (Int 10).

Aufarbeitung

  1. temperatureThe resulting mixture is refluxed overnight
  2. customThe mixture is then evaporated
  3. customthe obtained crude
  4. customis purified by chromatography

Quellen und Nachweise

ORD-Eintrag
ord-71b12c252fd04dada538bd59c20bb483
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09351955B2

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