Sodium Hydroxide → 4-(1-Hydroxy-1-methylethyl)-2-isopropoxymethyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acid

HRID 53002

Reaktionsgleichung

Reaktionsgleichung von HRID 53002
[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:34][O:35][CH:36]([CH3:38])[CH3:37])[N:8]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]3[NH:33][N:32]=[N:31][N:30]=3)=[CH:19][CH:18]=2)[C:9]=1[C:10]([O:12]C(C)C)=[O:11])([CH3:4])[CH3:3].[OH-].[Na+]>>[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:34][O:35][CH:36]([CH3:38])[CH3:37])[N:8]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]3[NH:33][N:32]=[N:31][N:30]=3)=[CH:19][CH:18]=2)[C:9]=1[C:10]([OH:12])=[O:11])([CH3:4])[CH3:3]

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 178459022Isopropyl 4-(1-hydroxy-1-methylethyl)-2-isopropoxymethyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

Produkt 1

HCID 1784590264-(1-Hydroxy-1-methylethyl)-2-isopropoxymethyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acidAusbeute 90 %

Versuchsvorschrift

A solution of 393 mg of isopropyl 4-(1-hydroxy-1-methylethyl)-2-isopropoxymethyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in Example 92(b)] in 3 ml of a 1N aqueous solution of sodium hydroxide was stirred at room temperature for 2 hours, and then insoluble matter was filtered off. 3 ml of 1N aqueous hydrochloric acid were added to the filtrate, and the precipitated amorphous powder was collected by filtration, to give 325 mg of the title compound, melting at 153°-161° C. (with softening).

Aufarbeitung

  1. filtrationinsoluble matter was filtered off
  2. addition3 ml of 1N aqueous hydrochloric acid were added to the filtrate
  3. filtrationthe precipitated amorphous powder was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-592cb2d46d1d46c9a7fb72f62a0994a5
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616599

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