2-propyl-1H-imidazole-4,5-dicarbonitrile → HCID 178450364, Verbindung

Reaktionsgleichung

[C:1]([C:4]1[N:5]=[C:6]([CH2:11][CH2:12][CH2:13]C)[NH:7][C:8]=1[C:9]#[N:10])(=[O:3])[CH3:2].[CH2:15](C1NC(C#N)=C(C#N)N=1)[CH2:16]C.C([Mg]Br)CC>>[C:1]([C:4]1[N:5]=[C:6]([CH2:11][CH2:12][CH3:13])[NH:7][C:8]=1[C:9]#[N:10])(=[O:3])[CH2:2][CH2:15][CH3:16]

Komponenten

Edukt 3

HCID 27637212-propyl-1H-imidazole-4,5-dicarbonitrile

HCID 178441657HCID 178441657, Verbindung

HCID 178455851HCID 178455851, Verbindung

Produkt 1

HCID 178450364HCID 178450364, VerbindungAusbeute 49,8 %

Versuchsvorschrift

Following a procedure similar to that described in Preparation 24(i), but using 2-propylimidazole-4,5-dicarbonitrile (prepared as described in Preparation 10) and propylmagnesium bromide, the title compound, melting at 94°-95° C., was obtained in a 49.8% yield.

Quellen und Nachweise

ORD-Eintrag: ord-57dbebaf2cb5498081be82cf04d0bd01
Quelldatensatz: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05616599

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