Potassium Carbonate → 1-(2-Methoxyethyl)piperidin-4-one

Temperatur

75 °C

4-Piperidone hydrochloride monohydrate (1.00 g, 6.50 mmol), 2-bromoethyl methyl ether (1.00 g, 7.20 mmol) and K2CO3 (1.80 g, 13.0 mmol) were dissolved in MeCN (20 mL) and the reaction mixture was stirred at 75° C. for 6 h. The reaction mixture was filtered and the solvents removed in vacuo. The residue was dissolved in DCM (30 mL), stirred with isocyanate resin for 2 h, dried (MgSO4) and concentrated in vacuo to give the crude title compound (180 mg, 18%) as a colourless gum.

1. filtrationThe reaction mixture was filtered
2. customthe solvents removed in vacuo
3. dissolutionThe residue was dissolved in DCM (30 mL)
4. stirringstirred with isocyanate resin for 2 h
5. dry with materialdried (MgSO4)
6. concentrationconcentrated in vacuo

ORD-Eintrag

ord-703300dc4a604252b4bcc5646298dad9

Quelldatensatz

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09353086B2