Dimethyl Sulfide → DMS bupivacaine

HRID 53078

Reaktionsgleichung

Reaktionsgleichung von HRID 53078
[CH3:1][S:2][CH3:3].[CH3:4][CH2:5][CH2:6][CH2:7][N:8]1[CH:13]([C:14]([NH:16][C:17]2[C:18]([CH3:24])=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:23])=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9]1>C(O)C>[CH3:1][S:2][CH3:3].[CH3:4][CH2:5][CH2:6][CH2:7][N:8]1[CH:13]([C:14]([NH:16][C:17]2[C:18]([CH3:24])=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:23])=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9]1

Komponenten

4

Edukt 2

HCID 1068Dimethyl SulfideHCID 2474Bupivacaine (USAN:INN:BAN)

Produkt 1

HCID 131719970DMS bupivacaine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A uniform mixture of DMS and bupivacaine was formed by combining DMS dissolved in 95% ethanol with bupivacaine dissolved in 95% ethanol. The solution was air-dried under the hood at room temperature until the ethanol evaporated and left behind a well-dispersed mixture of dry crystalline DMS and bupivacaine. The crystalline mixture was pulverized under mortar and pestle and combined with copolymer. The rest of the procedures followed those described for CHP PLAMs. All DMS/bupivacaine PLAMs were synthesized using large bore Teflon® tubing.

Aufarbeitung

  1. dry with materialThe solution was air-dried under the hood at room temperature until the ethanol
  2. customevaporated
  3. waitleft behind a well-dispersed mixture of dry crystalline DMS and bupivacaine

Quellen und Nachweise

ORD-Eintrag
ord-bea38d61458940fea2cd3e1c387f5571
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05618563

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