Triethylsilane → N-(3-hydroxy-3-(hydroxy(phenyl)methyl)cyclohexyl)-3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamide

HRID 530861Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 530861
[C:1]([C:9]1([OH:53])[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][C:16]([C:18]2[CH:19]=[C:20]3[C:24](=[CH:25][CH:26]=2)[N:23](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:22]=[C:21]3[C:46]2[CH:51]=[CH:50][N:49]=[C:48]([CH3:52])[CH:47]=2)=[O:17])[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[SiH](CC)(CC)CC>>[OH:53][C:9]1([CH:1]([OH:8])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][C:16]([C:18]2[CH:19]=[C:20]3[C:24](=[CH:25][CH:26]=2)[NH:23][N:22]=[C:21]3[C:46]2[CH:51]=[CH:50][N:49]=[C:48]([CH3:52])[CH:47]=2)=[O:17])[CH2:10]1

Komponenten

3

Edukt 2

HCID 12052TriethylsilaneHCID 67985165N-(3-benzoyl-3-hydroxycyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide

Produkt 1

HCID 57410537N-(3-hydroxy-3-(hydroxy(phenyl)methyl)cyclohexyl)-3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamide

Versuchsvorschrift

N-(3-Benzoyl-3-hydroxycyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide was stirred in neat TPA at room temperature for 10 minutes, and then Et3SiH (5 equiv.) was added. The reaction mixture was stirred at room temperature for 5 minutes, and then concentrated. The product was obtained after purification by reverse phase HPLC.

Aufarbeitung

  1. concentrationconcentrated
  2. customThe product was obtained
  3. customafter purification by reverse phase HPLC

Quellen und Nachweise

ORD-Eintrag
ord-dd5a8423c0a44a858154c5c26c799326
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09351965B2

Notizen zur Reaktion

Wird geladen…