Benzophenone imine → Methyl 3-(diphenylmethyleneamino)cyclohexanecarboxylate

HRID 530872Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 530872
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([O:10][CH3:11])=[O:9])[CH2:3]1.[C:12](=N)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>ClCCl>[C:13]1([C:12](=[N:1][CH:2]2[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([O:10][CH3:11])=[O:9])[CH2:3]2)[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Komponenten

4

Edukt 2

HCID 136809Benzophenone imineHCID 13216966Methyl 3-aminocyclohexane-1-carboxylate

Produkt 1

HCID 86698247Methyl 3-(diphenylmethyleneamino)cyclohexanecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In a flask, methyl 3-aminocyclohexanecarboxylate (3.86 g, 19.94 mmol) was dissolved in dichloromethane (80 mL). Benzophenone imine (3.33 mL, 19.94 mmol) was added to the reaction, and the reaction was stirred at room temperature for 24 hrs. Upon completion, the reaction was concentrated and triturated with diethyl ether. The suspension was filtered. This trituration process was done twice. The remaining filtrate was concentrated and progressed to the next step without further purification.

Aufarbeitung

  1. concentrationUpon completion, the reaction was concentrated
  2. customtriturated with diethyl ether
  3. filtrationThe suspension was filtered
  4. concentrationThe remaining filtrate was concentrated
  5. customprogressed to the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-2d8b0faaa1744303bd7cbe87e74a3fe9
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09351965B2

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