Trifluoroacetic acid → methyl 1-(4-fluorobenzyl)-3-(3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamido)cyclohexanecarboxylate

HRID 530876Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 530876
[F:1][C:2]1[CH:56]=[CH:55][C:5]([CH2:6][C:7]2([C:51]([O:53][CH3:54])=[O:52])[CH2:12][CH2:11][CH2:10][CH:9]([NH:13][C:14]([C:16]3[CH:17]=[C:18]4[C:22](=[CH:23][CH:24]=3)[N:21](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:20]=[C:19]4[C:44]3[CH:49]=[CH:48][N:47]=[C:46]([CH3:50])[CH:45]=3)=[O:15])[CH2:8]2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O.C([SiH](CC)CC)C>>[F:1][C:2]1[CH:56]=[CH:55][C:5]([CH2:6][C:7]2([C:51]([O:53][CH3:54])=[O:52])[CH2:12][CH2:11][CH2:10][CH:9]([NH:13][C:14]([C:16]3[CH:17]=[C:18]4[C:22](=[CH:23][CH:24]=3)[NH:21][N:20]=[C:19]4[C:44]3[CH:49]=[CH:48][N:47]=[C:46]([CH3:50])[CH:45]=3)=[O:15])[CH2:8]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 67985845methyl 1-(4-fluorobenzyl)-3-(3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)cyclohexanecarboxylate

Produkt 1

HCID 67985855methyl 1-(4-fluorobenzyl)-3-(3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamido)cyclohexanecarboxylate

Versuchsvorschrift

In a flask, methyl 1-(4-fluorobenzyl)-3-(3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)cyclohexanecarboxylate (230 mg, 0.31 mmol) was reacted with trifluoroacetic acid (3 mL) for 1 hour. After reaction completion triethylsilane (0.1 mL) was added, and the reaction was stirred for an additional 15 minutes. The reaction was concentrated and rinsed with diethyl ether. The crude product was progressed to the next step without further purification.

Aufarbeitung

  1. additionwas added
  2. concentrationThe reaction was concentrated
  3. washrinsed with diethyl ether
  4. customThe crude product was progressed to the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c8d813e91f5349d69206a1ce63d87b7d
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09351965B2

Notizen zur Reaktion

Wird geladen…