Hydrochloric Acid → 3-(2-Fluorobenzyl)-3-(methoxymethyl)piperidine

HRID 530885Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 530885
Cl.[F:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][C:6]1([CH2:19][O:20][CH3:21])[CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1>O1CCOCC1>[F:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][C:6]1([CH2:19][O:20][CH3:21])[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67982981tert-Butyl 3-(2-fluorobenzyl)-3-(methoxymethyl)piperidine-1-carboxylate

Produkt 1

HCID 679832113-(2-Fluorobenzyl)-3-(methoxymethyl)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

Hydrochloric acid in dioxane (1.5 mL, 4M) was added to a flask containing tert-butyl 3-(2-fluorobenzyl)-3-(methoxymethyl)piperidine-1-carboxylate (0.415 g, 1.23 mmol). 1,4-dioxane (1.5 mL) was added to the reaction mixture. The reaction was allowed to stir for 4 hours. Upon reaction completion, the reaction was concentrated, and 337 mg of crude product was recovered and progressed to the next step without further purification.

Aufarbeitung

  1. customUpon reaction completion
  2. concentrationthe reaction was concentrated
  3. custom337 mg of crude product was recovered
  4. customprogressed to the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-b356c715e813422683ff34ee5596f4b2
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09351965B2

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