4,5-Dicyclopropyl-2-ethoxybenzenemethanol → 4,5-Dicyclopropyl-2-ethoxybenzaldehyde

HRID 531055Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 531055
[CH:1]1([C:4]2[C:9]([CH:10]3[CH2:12][CH2:11]3)=[CH:8][C:7]([CH2:13][OH:14])=[C:6]([O:15][CH2:16][CH3:17])[CH:5]=2)[CH2:3][CH2:2]1>[O-2].[O-2].[Mn+4].C1(C)C=CC=CC=1>[CH:1]1([C:4]2[C:9]([CH:10]3[CH2:12][CH2:11]3)=[CH:8][C:7]([CH:13]=[O:14])=[C:6]([O:15][CH2:16][CH3:17])[CH:5]=2)[CH2:3][CH2:2]1

Komponenten

4

Edukt 1

HCID 904239324,5-Dicyclopropyl-2-ethoxybenzenemethanol

Produkt 1

HCID 904236504,5-Dicyclopropyl-2-ethoxybenzaldehydeAusbeute 95,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Manganese dioxide (8.50 g) was added at room temperature to a toluene (50 mL) solution of (4,5-dicyclopropyl-2-ethoxyphenyl)methanol (2.84 g) in a nitrogen atmosphere, and the mixture was stirred at 80° C. for 1 hour. The reaction mixture was filtered through celite, and then, the filtrate was concentrated. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (2.68 g).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated
  3. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-77514b2c7a8641898ea80573a13b4059
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09353108B2

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