Hydrochloric Acid → Ethyl 5-oxo-6-(piperidin-4-yl)-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate dihydrochloride monohydrate

HRID 531147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 531147
C([O:5]C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:23][CH2:22][C:21]3[N:20]=[C:19]([CH2:24][CH2:25][CH3:26])[C:18]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:17][C:16]=3[C:15]2=[O:32])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:33].C(OC(C)C)(C)C>>[OH2:5].[ClH:33].[ClH:33].[O:32]=[C:15]1[N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:23][CH2:22][C:21]2[N:20]=[C:19]([CH2:24][CH2:25][CH3:26])[C:18]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:17][C:16]1=2

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 117992199Ethyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)-5-oxo-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate

Produkt 1

HCID 131735653Ethyl 5-oxo-6-(piperidin-4-yl)-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate dihydrochloride monohydrate

Versuchsvorschrift

Ethyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)-5-oxo-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate (14.9 g) was added to 2M hydrogen chloride (ethanol solution, 167 mL) at room temperature. The mixture was stirred for 4 hours. Diisopropyl ether (1.00 L) was added to the reaction mixture. The mixture was stirred for 30 minutes. The precipitate was collected by filtration, washed with diisopropyl ether, dried under reduced pressure to give the title compound (13.7 g).

Aufarbeitung

  1. stirringThe mixture was stirred for 30 minutes
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with diisopropyl ether
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-60b79dbbdec34d059cd50d039549ce4d
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09353108B2

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