Sodium Hydroxide → 4-(4-Fluoro-2-((tetrahydro-2-H-pyran-4-yl)methoxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

HRID 532290Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 532290
C[O:2][C:3]([C:5]1[S:29][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][CH2:22][CH:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[C:7]=2[C:6]=1[CH3:30])=[O:4].[OH-].[Na+]>C(O)C.ClCCl.Cl>[F:20][C:17]1[CH:18]=[CH:19][C:14]([NH:13][C:12]2[C:7]3[C:6]([CH3:30])=[C:5]([C:3]([OH:4])=[O:2])[S:29][C:8]=3[N:9]=[CH:10][N:11]=2)=[C:15]([O:21][CH2:22][CH:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[CH:16]=1

Komponenten

6

Edukt 2

HCID 14798Sodium HydroxideHCID 58413397Methyl-4-(4-fluoro-2-((tetrahydro-2-H-pyran-4-yl)methoxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

Produkt 1

HCID 584133504-(4-Fluoro-2-((tetrahydro-2-H-pyran-4-yl)methoxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 313Hydrochloric AcidLösungsmittelHCID 702EthanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Methyl-4-(4-fluoro-2-((tetrahydro-2-H-pyran-4-yl)methoxy)phenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (82 mg) and NaOH (2M; 0.5 ml) was dissolved in ethanol (2 ml). The reaction was stirred at room temperature overnight. Then the reaction mixture was diluted with dichloromethane and HCl (2M). The suspension was filtered, washed with brine and ether. The residue was dried in vacuo over P2O5.

Aufarbeitung

  1. filtrationThe suspension was filtered
  2. washwashed with brine and ether
  3. dry with materialThe residue was dried in vacuo over P2O5

Quellen und Nachweise

ORD-Eintrag
ord-ddeaacbfc298488796da70ee55d7cc81
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08853193B2

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