HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethanolamine → 4-(2-(2-Fluoropropoxy)pyridin-3-ylamino)-N-(2-hydroxyethyl)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethanolamine | HCID 700 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Edukt | 4-(2-(2-Fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid | HCID 58413252 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 4-(2-(2-Fluoropropoxy)pyridin-3-ylamino)-N-(2-hydroxyethyl)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide | HCID 58413343 | — |
Reaktionsschritte
4-(2-(2-Fluoropropoxy)pyridin-3-ylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid (36.2 mg), HATU (42 mg) and Hünig's base (34 μl) were dissolved in DMF (2 ml) and ethanolamine (9 μl) was added. The reaction was stirred at room temperature for 2 h. The reaction mixture was purified directly by chromatography.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08853193B2 |
| Quelldatensatz | uspto-grants-2014_10 |
| ORD ID | ord-043f359bc85545e1a2250c57c9a0205d |
| Quellennotiz | uspto-grants-2014_10 |