1,1-Dibromoethane → 2-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine

HRID 5327

Reaktionsgleichung

Reaktionsgleichung von HRID 5327
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[S:11])[CH:6]=[CH:7][CH:8]=1.Br[CH:21](Br)[CH3:22].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:16]([O:15][C:13]([N:12]=[C:10]1[N:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:18])([F:1])[F:19])[CH:4]=2)[CH2:22][CH2:21][S:11]1)=[O:14])[CH3:17]

Komponenten

5

Edukt 3

HCID 112011,1-DibromoethaneHCID 11430Potassium CarbonateHCID 971062Ethyl N-{[3-(trifluoromethyl)phenyl]carbamothioyl}carbamate

Produkt 1

HCID 542258332-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidineAusbeute 83,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A solution of N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea (1.8 g), dibromoethane (1.29 g) and anhydrous potassium carbonate (2.6 g) in acetone (20 ml) was refluxed for 5 hours. The solvent was removed by distillation, and the residue was extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from a mixture of hexane and ethanol to give 1.63 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine. m.p., 75.8° C.

Aufarbeitung

  1. customThe solvent was removed by distillation
  2. extractionthe residue was extracted with diethyl ether
  3. washThe extract was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was recrystallized from a mixture of hexane and ethanol

Quellen und Nachweise

ORD-Eintrag
ord-fa8d09f785da43d08f3fafc57bc6778e
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05244863

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