Hydrochloric Acid → 4-(8-[1,4]Diazepan-1-yl-6-methyl-quinolin-7-yloxy)-butyric acid methyl ester

HRID 532849Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 532849
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[C:16]([O:26][CH2:27][CH2:28][CH2:29][C:30]([O:32][CH3:33])=[O:31])=[C:17]([CH3:25])[CH:18]=[C:19]3[C:24]=2[N:23]=[CH:22][CH:21]=[CH:20]3)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.O1CCOCC1>[CH3:33][O:32][C:30](=[O:31])[CH2:29][CH2:28][CH2:27][O:26][C:16]1[C:15]([N:11]2[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]2)=[C:24]2[C:19]([CH:20]=[CH:21][CH:22]=[N:23]2)=[CH:18][C:17]=1[CH3:25]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 593661754-[7-(3-Methoxycarbonyl-propoxy)-6-methyl-quinolin-8-yl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 593662074-(8-[1,4]Diazepan-1-yl-6-methyl-quinolin-7-yloxy)-butyric acid methyl esterAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

The product from step 1 was dissolved in MeOH (18.8 mL) and HCl was added (4M in dioxane, 18.8 mL, 75.2 mmol). The reaction was stirred at room temperature for 2 h, then concentrated. CH2Cl2 was added and this solution was washed with sat. aq. NaHCO3, then brine. The organic was dried over MgSO4, filtered, and concentrated to give the product (1.30 g, 96% yield) as an oil.

Aufarbeitung

  1. concentrationconcentrated
  2. additionCH2Cl2 was added
  3. washthis solution was washed with sat. aq. NaHCO3
  4. dry with materialThe organic was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-3bd1608b3d244649b1b88e71e4d88d3d
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08853202B2

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