HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → Ethyl 3-(3-(methylsulfonyloxy)propyl)-1h-indole-2-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Methanesulfonyl chloride | HCID 31297 | — |
| Edukt | ethyl 3-(3-hydroxypropyl)-1H-indole-2-carboxylate | HCID 67316234 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | Ethyl 3-(3-(methylsulfonyloxy)propyl)-1h-indole-2-carboxylate | HCID 87353567 | — |
Reaktionsschritte
To a mixture of EXAMPLE 3A (0.125 g) and triethylamine (0.21 mL) in acetonitrile (3 mL) at 0-5° C. was added methanesulfonyl chloride (0.0404 mL). After 30 minutes, the mixture was concentrated, and the concentrate was purified by flash chromatography on silica gel with 0-30% ethyl acetate/hexanes.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08853209B2 |
| Quelldatensatz | uspto-grants-2014_10 |
| ORD ID | ord-22d6a533025f46338385244e57eb3a97 |
| Quellennotiz | uspto-grants-2014_10 |