N-bromobutanimide → HCID 67315809, Verbindung

HRID 533263Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 533263
[C:1]1([CH3:20])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[C:10]([C:16]([O:18][CH3:19])=[O:17])[NH:11]2.[Br:21]N1C(=O)CCC1=O>ClCCl.O1CCCC1>[Br:21][C:9]1[C:8]2[C:12](=[CH:13][CH:14]=[CH:15][C:7]=2[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[CH3:20])[NH:11][C:10]=1[C:16]([O:18][CH3:19])=[O:17]

Komponenten

5

Edukt 2

HCID 67184N-bromobutanimideHCID 67316099Methyl 4-o-tolyl-1h-indole-2-carboxylate

Produkt 1

HCID 67315809HCID 67315809, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a solution of EXAMPLE 126A (205 mg) in dichloromethane (5 ml) and tetrahydrofuran (5 ml) at 0° C. was added dropwise N-bromosuccinimide (144 mg) in tetrahydrofuran (3 ml). The mixture was stirred while the ice bath slowly reached room temperature. The reaction mixture was concentrated and the residue was dissolved in dichloromethane and purified by flash chromatography, eluting with 0-100% dichloromethane in hexane to provide the desired product.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in dichloromethane
  3. custompurified by flash chromatography
  4. washeluting with 0-100% dichloromethane in hexane

Quellen und Nachweise

ORD-Eintrag
ord-b2f43dd451ea4acfa5b0f0aceb442233
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08853209B2

Notizen zur Reaktion

Wird geladen…