4-Bromo-2-fluorobenzeneethanol → 4-Bromo-1-(2-iodo-ethyl)-2-fluoro-benzene
Reaktionsgleichung
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][I:10])=[C:4](C)[CH:3]=1.BrC1C=CC(CCO)=C([F:22])C=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][I:10])=[C:4]([F:22])[CH:3]=1Komponenten
3
Versuchsvorschrift
The title compound was synthesized according to the same general procedure described for the synthesis of 4-bromo-1-(2-iodo-ethyl)-2-methyl-benzene in Preparation #2, Step 1, except that 2-(4-bromo-2-fluoro-phenyl)-ethanol was used instead of 2-(4-bromo-2-methylphenyl)ethanol to yield the title compound as a clear oil (5.75 g, 95.7%) 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 3.13-3.24 (m, 2H) 3.26-3.44 (m, 2H) 7.06-7.14 (m, 1H) 7.21-7.24 (m, 1H) 7.26-7.31 (m, 1H)
Aufarbeitung
- customThe title compound was synthesized
Quellen und Nachweise
- ORD-Eintrag
- ord-34e45b30f5544b6a89087a7014072a98
- Quelldatensatz
- uspto-grants-2014_10
- Patentnummer
- US08853258B2
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