Methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylate → HCID 178418571, Verbindung

HRID 5341Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 5341
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[N:23]=[C:22]([C:24](OC)=[O:25])[CH:21]=[CH:20][N:19]=3)[CH2:10][CH2:9]2)[CH:7]=1.[NH2:30][CH2:31][CH2:32][NH:33][C:34]1[NH:35][CH:36]=[CH:37][C:38](=[O:40])[N:39]=1>C(O)CCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[N:23]=[C:22]([C:24]([NH:30][CH2:31][CH2:32][NH:33][C:34]4[NH:35][CH:36]=[CH:37][C:38](=[O:40])[N:39]=4)=[O:25])[CH:21]=[CH:20][N:19]=3)[CH2:12][CH2:13]2)[CH:7]=1

Komponenten

4

Edukt 2

HCID 19013272Methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylateHCID 178418575HCID 178418575, Verbindung

Produkt 1

HCID 178418571HCID 178418571, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

1.89 g of (4.5 mmols) of methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylate and 0.77 g (5 mmols) of 2-[(2-aminoethyl)amino]pyrimidin-4(1H)-one in 5 ml of n-butanol are introduced into a 25 ml, round bottomed flask. The mixture is heated at the reflux temperature of the solvent for 15 hours and then the solvent is evaporated under reduced pressure.

Aufarbeitung

  1. temperatureThe mixture is heated at the reflux temperature of the solvent for 15 hours
  2. customthe solvent is evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-682b7c7c9d9d4c65b29faad31f704d69
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05244894

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