2-Chloronicotinoyl chloride → N-(2-bromo-6-methoxy-4-methyl-3-pyridinyl)-2-chloro-3-pyridinecarboxamide

HRID 53531

Reaktionsgleichung

Reaktionsgleichung von HRID 53531
[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[NH2:11][C:12]1[C:13]([Br:21])=[N:14][C:15]([O:19][CH3:20])=[CH:16][C:17]=1[CH3:18]>C(Cl)Cl>[Br:21][C:13]1[C:12]([NH:11][C:4]([C:3]2[C:2]([Cl:1])=[N:10][CH:9]=[CH:8][CH:7]=2)=[O:5])=[C:17]([CH3:18])[CH:16]=[C:15]([O:19][CH3:20])[N:14]=1

Komponenten

4

Edukt 2

HCID 27745412-Chloronicotinoyl chlorideHCID 199600552-Bromo-6-methoxy-4-methylpyridin-3-amine

Produkt 1

HCID 19960021N-(2-bromo-6-methoxy-4-methyl-3-pyridinyl)-2-chloro-3-pyridinecarboxamideAusbeute 84,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-Chloronicotinoyl chloride (3.5 g) was added to a solution of 3-amino-2-bromo-6-methoxy-4-methylpyridine (4.5 g) in methylene chloride, and the resulting mixture was stirred overnight at room temperature, and triturated with diisopropyl ether. The precipitated solid was filtered to give 6.0 g of the title compound, suitable for use in the next reaction.

Aufarbeitung

  1. customtriturated with diisopropyl ether
  2. filtrationThe precipitated solid was filtered

Quellen und Nachweise

ORD-Eintrag
ord-6a0646106c7b4305a06b3cf1bf22313a
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05620974

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