Aniline → 5,7,8-Tetrahydro-N-phenyl-6-(phenylmethyl)pyrido[4,3-D]pyrimidin-4-amine

HRID 535345Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 535345
[CH2:1]([N:8]1[CH2:18][CH2:17][C:11]2[N:12]=[CH:13][N:14]=[C:15](Cl)[C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(#N)C>[CH2:1]([N:8]1[CH2:18][CH2:17][C:11]2[N:12]=[CH:13][N:14]=[C:15]([NH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 6115AnilineHCID 253240466-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido(4,3-d)pyrimidine2×

Produkt 1

HCID 3179555,7,8-Tetrahydro-N-phenyl-6-(phenylmethyl)pyrido[4,3-D]pyrimidin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
180 °C

Versuchsvorschrift

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (Intermediate 2, 1.0 g, 3.86 mmol) was dissolved in anhydrous acetonitrile (3 mL) and aniline was added (0.39 mL, 4.24 mmol). The mixture was heated at 180° C. for 600 s in a microwave (Emrys Optimizer model, Personal Chemistry). The solvents were removed under vacuum to give the desired product as a beige powder (1.5 g, quant.). The crude product was used as such for the subsequent step.

Aufarbeitung

  1. customThe solvents were removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-883dbe55f8484d0094ad698ade339cad
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859545B2

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